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Arboviral Encephalitis

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Updated: Mar 23, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

Rhombencephalitis associated with Dengue fever.

Rajesh Verma¹, Kavita Bharti¹, Mannan Mehta¹

¹Neurology King George Medical University, Lucknow, UP, India.

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology

|March 26, 2016

Summary

Dengue fever, a mosquito-borne arbovirus infection, can cause serious neurological issues. This report details a rare case of rhombencephalitis, a brainstem inflammation, linked to dengue illness.

Keywords:

Arbovirus Dengue fever Encephalitis Listerosis Neurological complications Rhombencephalitis

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Area of Science:

Neurology
Infectious Diseases
Arbovirology

Background:

Dengue fever is a globally spreading arbovirus infection transmitted by Aedes mosquitoes.
Neurological complications are increasingly recognized in dengue fever patients.
Central nervous system disorders like encephalopathy, encephalitis, and myelitis are known dengue complications.

Observation:

This study reports a unique case of rhombencephalitis associated with dengue fever.
Rhombencephalitis, an inflammation of the brainstem, has not been previously documented in relation to dengue illness.

Findings:

A patient presented with rhombencephalitis concurrently with dengue fever.
This case expands the spectrum of known neurological manifestations of dengue virus infection.

Implications:

The findings suggest rhombencephalitis should be considered in the differential diagnosis of neurological complications in dengue patients.
Further research is warranted to understand the mechanism and incidence of rhombencephalitis in dengue infections.