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Intracerebral Transplantation and In Vivo Bioluminescence Tracking of Human Neural Progenitor Cells in the Mouse Brain

Intracerebral Transplantation and In Vivo Bioluminescence Tracking of Human Neural Progenitor Cells in the Mouse Brain

Published on: January 27, 2022

Restoring motor function using optogenetics and neural engraftment.

J Barney Bryson¹, Carolina Barcellos Machado², Ivo Lieberam²

¹Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London WC1E 3BG, United Kingdom.

Current Opinion in Biotechnology

|March 27, 2016

Summary

This summary is machine-generated.

Restoring motor function after spinal cord injury (SCI) and amyotrophic lateral sclerosis (ALS) is challenging. This review explores stem cell therapies and optogenetics for artificial muscle control.

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Last Updated: Mar 23, 2026

Intracerebral Transplantation and In Vivo Bioluminescence Tracking of Human Neural Progenitor Cells in the Mouse Brain

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Published on: January 27, 2022

Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains

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Published on: June 8, 2018

Optogenetic Manipulation of Neuronal Activity to Modulate Behavior in Freely Moving Mice

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Published on: October 27, 2020

Area of Science:

Neuroscience
Regenerative Medicine
Biotechnology

Background:

Motor function control is vital for survival and behavior.
Impaired motor function, seen in spinal cord injury (SCI) and amyotrophic lateral sclerosis (ALS), severely impacts life quality and can be life-threatening.
Current repair strategies for damaged motor circuits in SCI and ALS are limited.

Purpose of the Study:

To review recent advancements in restoring motor function.
To focus on stem cell-derived neuronal engraftment and optogenetic control strategies.
To discuss the potential for future translational applications of these motor restoration approaches.

Main Methods:

Review of current literature on stem cell therapies for neuronal engraftment.
Analysis of optogenetic techniques for controlling motor function.
Evaluation of the translational potential of emerging restorative strategies.

Main Results:

Stem cell-derived neuronal engraftment shows promise for repairing damaged neural circuits.
Optogenetic methods offer precise control over muscle activation.
Significant progress is being made in developing artificial control strategies for motor function.

Conclusions:

Restoring motor function in conditions like SCI and ALS requires innovative approaches beyond traditional repair.
Stem cell therapies and optogenetics represent key emerging strategies for artificial muscle control.
Further research and development are crucial for the clinical translation of these promising technologies.