Related Experiment Video

Updated: Mar 23, 2026

Electrophysiological Measurements and Analysis of Nociception in Human Infants
09:18

Electrophysiological Measurements and Analysis of Nociception in Human Infants

Published on: December 20, 2011

17.8K

Infant Colic

Amy A Gelfand1

  • 1Departments of Neurology and Pediatrics, University of California San Francisco (UCSF), San Francisco, CA.

Seminars in Pediatric Neurology
|March 28, 2016
PubMed

Insights

Infant colic, characterized by excessive crying, is linked to migraine. Research suggests a connection, prompting a review of migraine-oriented treatments for colicky infants.

Area of Science:

  • Neurology
  • Pediatrics
  • Gastroenterology

Background:

  • Infant colic affects 5%-19% of infants and is often attributed to gastrointestinal issues.
  • Previous treatments targeting gastrointestinal causes for infant colic have yielded negative results.
  • Parental education on managing inconsolable crying is crucial for preventing shaken baby syndrome.

Purpose of the Study:

  • To review the evidence associating infant colic with migraine.
  • To explore potential migraine-specific mechanisms and treatments for infant colic.

Main Methods:

  • Review of multiple case-control studies.
  • Inclusion of a cross-sectional study.
  • Analysis of a prospective cohort study.

Main Results:

  • Consistent evidence across study types indicates an association between infant colic and migraine.
  • The gastrointestinal etiology assumption for infant colic is challenged by negative treatment trial outcomes.

Conclusions:

  • Accumulating evidence supports a link between infant colic and pediatric migraine.
  • Future research should investigate migraine-oriented treatments for infant colic.
  • Infant colic may warrant classification as an "Episodic syndrome that may be associated with migraine" in ICHD-III beta.

More Related Videos

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers09:36

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers

Published on: July 28, 2022

2.7K
A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis05:39

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis

Published on: November 30, 2021

4.2K

Related Concept Videos

Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
720
Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
1.4K
Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid...
11
Pathophysiology of Vomiting01:22

Pathophysiology of Vomiting

Vomiting is a complex physiological response to expel harmful or irritating substances from the body. It's a defensive mechanism triggered by stimuli like poisons, microbial toxins, cytotoxic drugs, and mechanical abdominal distension. The process is centrally coordinated by the vomiting (or emetic) center located in the medulla of the brainstem. This area, rich in muscarinic M1, histamine H1, neurokinin 1 (NK1), and serotonin 5-HT3 receptors, coordinates the act of vomiting through...
3.9K
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation01:30

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
1.0K
Gastrointestinal Motility Disorders01:20

Gastrointestinal Motility Disorders

Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...
1.5K