[EPIGENETIC ENZYMES AS THERAPEUTIC TARGETS FOR TREATING BRAIN DISORDERS]
Eksperimental'Naia I Klinicheskaia Farmakologiia
|March 29, 2016
Summary
Histone deacetylase inhibitors (HDACIs) show promise for treating brain disorders by correcting epigenetic dysregulation. These compounds target histone acetylation imbalances linked to neurodegenerative and cognitive conditions.
Area of Science:
- Epigenetics and Molecular Biology
- Neuroscience
- Pharmacology
Context:
- Epigenetic regulation, including DNA methylation and histone acetylation, is crucial for cellular adaptation.
- Imbalances in histone acetylation and transcriptional activity are implicated in various brain diseases.
- Histone deacetylase enzymes (HDACs) are key regulators of chromatin structure and gene expression.
Purpose:
- To review the therapeutic potential of histone deacetylase inhibitors (HDACIs) for neurological and mental illnesses.
- To summarize the development and application of HDACIs in treating brain pathologies.
- To highlight HDACIs as a promising therapeutic strategy for neurodegenerative, ischemic, and cognitive disorders.
Summary:
- Histone deacetylase inhibitors (HDACIs) modulate protein acetylation, offering a therapeutic approach for brain disorders.
- Evidence links histone hypoacetylation and transcriptional dysfunction to neurodegenerative conditions.
- HDACIs represent a class of compounds being investigated for treating human brain diseases.
Impact:
- HDACIs offer a novel therapeutic avenue for correcting epigenetic deficiencies in brain disorders.
- The development of HDACIs provides a promising strategy for neuroprotection and cognitive enhancement.
- Clinical testing of various HDACIs is ongoing, paving the way for new treatments for neurological and mental illnesses.
More Related Videos
09:56Epigenetic Engineering of K562 Cells: Dual-Vector Episomal Strategy for Stable Targeted DNA Methylation using dCas9-DNMT3A and -HDAC1 Fusion Proteins
Published on: October 31, 2025
580
10:28Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
Published on: September 20, 2018
7.0K
Related Concept Videos
01:37Epigenetic Regulation
4.1K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
4.1K
01:46Epigenetic Regulation
34.2K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
34.2K
01:29Pharmacogenomics: Identification of New Drug Targets
76
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
76
01:30Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
813
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
813
01:29Drugs Affecting Neurotransmitter Synthesis
2.5K
Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase,...
2.5K
01:28Human Genetics
1.8K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
1.8K