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Updated: Mar 23, 2026
PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
Published on: December 27, 2013
Exemestane encapsulated vitamin E-TPGS-polymeric nanoparticles: preparation, optimization, characterization, and in
Brahmeshwar Mishra1, Ravi Padaliya1, Ravi R Patel1
1a Department of Pharmaceutics , Indian Institute of Technology (Banaras Hindu University ), Varanasi , India.
Abstract:
The objective of the present study was to formulate and optimize exemestane (EXM) encapsulated vitamin E-TPGS-poly-ɛ-caprolactone based polymeric nanoparticles (TPGS-PCLNPs) for enhancing its anticancer efficacy. The 23 factorial design was employed to investigate the combined influence of formulation and process variables on properties of TPGS-PCLNPs, prepared by nanoprecipitation method. The physicochemical characterization revealed the encapsulation of EXM in amorphous form without any interaction inside spherical shaped TPGS-PCLNPs. In vitro cytotoxicity study on MCF-7 breast cancer cells exhibited enhanced cytotoxicity of EXM by encapsulating in TPGS-PCLNPs. The TPGS-PCLNPs can serve as potential delivery vehicle for EXM to improve its therapeutic efficacy.
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