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DNA-Based Nanostructured Platforms as Drug Delivery Systems
Manish Kumar1, Abhishek Jha1, Brahmeshwar Mishra1
1Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology, (BHU), Varanasi 221005, Uttar Pradesh, India.
Chem & Bio Engineering
|February 20, 2025
Summary
DNA nanostructures offer a safe, programmable platform for drug delivery, enhancing therapeutic effectiveness and reducing toxicity. This novel approach improves drug encapsulation and targeted delivery for various diseases.
Area of Science:
- Biotechnology
- Nanotechnology
- Materials Science
Background:
- DNA nanostructures present a novel, safe, and biocompatible approach for drug delivery systems.
- They offer advantages like programmable assembly, reproducibility, and precise control over size, shape, and function.
Purpose of the Study:
- To review DNA nanostructures for drug encapsulation and selective delivery.
- To highlight their potential in improving therapeutic effectiveness and reducing cytotoxicity.
Main Methods:
- Integration of DNA nanostructures with functional moieties (proteins, polymers, targeting groups) via conjugation.
- Development of 'smart' DNA nanostructures with targeting ligands or stimuli-responsive elements.
Main Results:
- DNA nanostructures enhance delivery of poorly soluble drugs, decrease cytotoxicity, and improve therapeutic outcomes.
- Smart DNA nanostructures enable targeted delivery, minimize off-target effects, and enhance cellular uptake.
Conclusions:
- DNA nanostructures represent a versatile and effective platform for advanced drug delivery.
- They hold significant potential for treating a wide range of diseases with improved efficacy and safety.
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