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Related Experiment Video

Updated: Mar 23, 2026

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EUS-guided fine needle biopsy sampling using a novel fork-tip needle: a case-control study.

Pujan Kandel1, Ghassan Tranesh2, Aziza Nassar2

  • 1Department of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida, USA.

Gastrointestinal Endoscopy
|March 29, 2016
PubMed
Summary
This summary is machine-generated.

The novel Shark Core (SC) needle significantly improves endoscopic ultrasound-guided fine needle biopsy (EUS-FNB) histology yield compared to standard EUS-FNA. This new needle requires fewer passes for adequate tissue samples, enhancing diagnostic accuracy for pancreatic and nonpancreatic lesions.

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Area of Science:

  • Gastroenterology
  • Pathology
  • Medical Devices

Background:

  • Endoscopic ultrasound-guided fine needle biopsy (EUS-FNB) and fine needle aspiration (EUS-FNA) are crucial for tissue acquisition.
  • Specimen quality is paramount for accurate pathologic evaluation.
  • A novel EUS-FNB Shark Core (SC) needle was developed to enhance core tissue acquisition.

Purpose of the Study:

  • To compare the histology yield of EUS-FNB using the Shark Core (SC) needle versus conventional EUS-FNA.
  • To evaluate the number of passes required to obtain adequate tissue samples with both methods.
  • To assess the efficacy of EUS-FNB-SC in patients with solid pancreatic and nonpancreatic lesions.

Main Methods:

  • Retrospective case-control study of patients undergoing EUS-FNB-SC and EUS-FNA between July 2012 and July 2015.
  • Matching of EUS-FNB-SC samples (1:3 ratio) to EUS-FNA samples by lesion site and needle gauge.
  • Histologic yield assessed by cytopathologists using a standard scoring system (0-5); rapid onsite evaluation was performed.

Main Results:

  • The EUS-FNB-SC group achieved a median histology score of 4 (adequate histology), compared to 2 (cytology only) for EUS-FNA.
  • Ninety-five percent of EUS-FNB-SC specimens were sufficient for histologic screening versus 59% for EUS-FNA (P=.01).
  • Significantly fewer passes were needed with EUS-FNB-SC (median 2 passes) compared to EUS-FNA (median 4 passes) (P=.001).

Conclusions:

  • The EUS-FNB-SC needle demonstrates a significantly higher histology yield than EUS-FNA.
  • Fewer needle passes are required to obtain adequate histology cores using the EUS-FNB-SC needle.
  • The Shark Core needle improves tissue acquisition for pathologic evaluation in EUS-guided procedures.