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Overexpression of angiotensin-converting enzyme in myelomonocytic cells enhances the immune response
Kenneth E Bernstein1, Zakir Khan1, Jorge F Giani1
1Department of Biomedical Sciences and the Department of Pathology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Abstract:
Angiotensin-converting enzyme (ACE) converts angiotensin I to the vasoconstrictor angiotensin II and thereby plays an important role in blood pressure control. However, ACE is relatively non-specific in its substrate specificity and cleaves many other peptides. Recent analysis of mice overexpressing ACE in monocytes, macrophages, and other myelomonocytic cells shows that these animals have a marked increase in resistance to experimental melanoma and to infection by Listeria monocytogenes or methicillin-resistant Staphylococcus aureus (MRSA). Several other measures of immune responsiveness, including antibody production, are enhanced in these animals. These studies complement a variety of studies indicating an important role of ACE in the immune response.
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