First episode psychosis in the over 35s: is there a role for early intervention?

Philippa Greenfield1, Snehita Joshi1, Suneel Christian1

  • 1Camden & Islington Early Intervention Service, Camden and Islington NHS Foundation Trust, London, UK.

Insights

Extending early intervention (EI) services to individuals over 35 with first episode psychosis (FEP) significantly increases workload. While some patients show recent onset, evidence on EI effectiveness in this older demographic is needed.

Area of Science:

  • Psychiatry
  • Clinical Psychology
  • Public Health

Background:

  • Early intervention (EI) models have demonstrated efficacy in improving outcomes for younger individuals experiencing psychosis.
  • There is growing interest in adapting EI for older populations, aligning with UK National Institute of Clinical Excellence recommendations for first episode psychosis (FEP) accessibility.

Purpose of the Study:

  • To investigate the potential impact of extending the age range for early intervention services on clinical workloads and patient populations.
  • To explore the characteristics and outcomes of individuals aged 36-65 referred to an early intervention service.

Main Methods:

  • Retrospective data collection from an inner London early intervention service (2011-2014).
  • Inclusion of all patients aged 36-65 years referred during the study period.
  • Utilized the MiData 2 tool for data collection at intake and 1-year follow-up.

Main Results:

  • Individuals aged 36-65 constituted 30% of all referrals.
  • The sample exhibited high rates of past trauma (62.5%), parental responsibilities (58.3%), and physical comorbidities (48.6%).
  • While inpatient admission rates were lower than in younger cohorts, only 15% achieved full remission after a single episode.

Conclusions:

  • Expanding early intervention services to individuals over 35 substantially increases service workload.
  • A significant proportion of older referrals presented with recent onset of illness, suggesting potential benefit from early intervention.
  • Further research is required to establish the effectiveness of early intervention models for psychosis in this older age group.
Abstract

Related Concept Videos

Schizophrenia01:17

Schizophrenia

Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
1.5K
Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
1.1K
Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
660
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
810
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
2.4K
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
345