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Updated: Mar 23, 2026

A Scalable Balz-Schiemann Reaction Protocol in a Continuous Flow Reactor
Published on: February 10, 2023
High-Throughput Screening Protocol for the Coupling Reactions of Aryl Halides Using a Colorimetric Chemosensor for
Min Sik Eom1, Jieun Noh2, Han-Sung Kim2
1Department of Chemistry, Gwangju Institute of Science of Technology (GIST) , Gwangju 61005, Republic of Korea.
Abstract:
Mercury complex of 4-(2-pyridylazo)resorcinol (PAR-2Hg(2+)), a halide-ion chemosensor, was prepared and its efficiency as a tool for high-throughput screening (HTS) of transition-metal-catalyzed coupling reactions was investigated. It showed a high selectivity for halide ions. When the PAR-2Hg(2+) complex was used in the Suzuki coupling reaction and C-H activated coupling reaction with aryl bromides, the quantitative and qualitative conversions of aryl halides were obtained from the reaction mixture color change.
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