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HLA genes as modifiers of response to IFN-β-1a therapy in relapsing-remitting multiple sclerosis
Mehrdokht Mazdeh1, Mohammad Taheri2, Arezou Sayad2
1Department of Neuroogy, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Aims:
This study investigated the influence of HLA class-I and -II genes in the response to IFN-β in relapsing-remitting multiple sclerosis (MS) patients.
Patients & Methods:
In this cohort, 231 relapsing-remitting MS patients who are classified into IFN-β responders (n = 146) and nonresponders (n = 85) and 180 ethnic-matched healthy controls were analyzed. Clinical outcome of IFN-β therapy particularly Expanded Disability Status Scale scores were evaluated in relation to HLA-A, -B and -DRB1 alleles and haplotypes.
Results:
Increased frequencies of HLA-DRB1*04 allele and HLA-A*03-B*44-DRB1*04 haplotype, and decreased frequency of HLA-B*15 were associated with better response to IFN-β treatment.
Conclusion:
The possibility of genetic screening particularly HLA typing prior to starting IFN-β therapy for MS may permit the identification of likely responders or nonresponders.
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