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Passive tumour targeting and extravasation of cylindrical polymer brushes in mouse xenografts
Markus Müllner1, Dharmini Mehta2, Cameron J Nowell3
1Key Centre for Polymers and Colloids, School of Chemistry, The University of Sydney, Sydney 2006, New South Wales, Australia. markus.muellner@sydney.edu.au.
Abstract:
The shape-persistent nature and conformation of cylindrical polymer brushes (CPBs) present opportunities to explore the properties of anisotropic (i.e. non spherical) nanomaterials in biological settings. This study shows that CPBs with lengths of up to 1 μm are able to passively target tumours via the enhanced permeation and retention (EPR) effect. Moreover, large CPBs with higher aspect ratios (ARs) were able to penetrate tumours with similar efficiencies to much smaller systems with lower ARs.
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