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Opsoclonus-Myoclonus Syndrome in Primary Central Nervous System Lymphoma
Joseph Grubbs1, Jonathan D Trobe, Amanda Fisher-Hubbard
1Departments of Ophthalmology and Visual Sciences (JG, JDT), Neurology (JDT) and Pathology (Neuropathology) (AFH), Kellogg Eye Center, University of Michigan Medical System, Ann Arbor, Michigan.
Abstract:
Adult-onset opsoclonus-myoclonus syndrome (OMS) has been associated with multiple cancers, most commonly small-cell lung carcinoma and breast adenocarcinoma. A 53-year-old woman who presented with OMS was found to have primary central nervous system (CNS) diffuse large B-cell lymphoma. OMS has been described in only 5 cases with non-Hodgkin lymphoma (NHL), and this is only the third reported case of OMS in NHL limited to the CNS. Although the paraneoplastic antibody panel was negative, we presume that the OMS was a paraneoplastic manifestation. Antineoplastic and anti-immune therapy had no effect on the neurologic manifestations.
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