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Related Concept Videos

Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

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As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
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Microtubules are hollow cylindrical filaments having a diameter of approximately 25 nm and a length that varies from 200 nm to 25 μm. GTP-bound tubulin subunits form αβ-heterodimers for microtubule assembly. These core building blocks interact longitudinally, polymerizing into protofilaments. The protofilaments then interact with one another through lateral bonding forces to form stable cylindrical microtubules. These cylindrical filaments are dynamic as they undergo repeated...
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Related Experiment Video

Updated: Mar 23, 2026

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
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[MICROSATELLITE INSTABILITY IN ENDOMETRIAL CANCER].

St Stoyanov, E Aleksandrova, K Ivanova

    Akusherstvo I Ginekologiia
    |March 31, 2016
    PubMed
    Summary
    This summary is machine-generated.

    Microsatellite instability (MSI), a DNA mismatch repair deficiency, is crucial in endometrial cancer development and prognosis. This review details MSI

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    Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
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    Area of Science:

    • Oncology and Molecular Biology: Focuses on cancer pathogenesis and DNA repair mechanisms.

    Context:

    • Microsatellite instability (MSI) is implicated in approximately 30% of endometrial cancer cases.
    • MSI has demonstrated significant clinical and prognostic value in recent research.

    Purpose:

    • To elucidate the components and molecular mechanisms of the DNA mismatch repair (MMR) system.
    • To review the correlation between MSI and endometrial cancer, highlighting mutation accumulation pathways.

    Summary:

    • MSI is a key indicator of endometrial tumors with MMR deficiency.
    • Errors in microsatellite repeat replication lead to mutations in coding and non-coding DNA.

    Impact:

    • Provides a comprehensive overview of MSI in endometrial cancer.
    • Enhances understanding of DNA repair deficiencies and their role in tumorigenesis.