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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

345
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
345
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

311
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
311
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

314
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
314
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

799
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
799
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

330
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
330
Drug Therapy01:28

Drug Therapy

391
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
391

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Related Experiment Video

Updated: Mar 23, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

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Antimicrobial Stewardship for a Geriatric Behavioral Health Population.

Kristen Ellis1,2, Georgina Rubal-Peace3, Victoria Chang4

  • 1Banner Medical University Center South, 2800 E Ajo Way, Tucson, AZ 85713, USA. ellis@pharmacy.arizona.edu.

Antibiotics (Basel, Switzerland)
|March 31, 2016
PubMed
Summary
This summary is machine-generated.

Pharmacist interventions significantly improved antimicrobial prescribing on a geriatric psychiatric unit, reducing inappropriate doses and durations. This enhances patient care and combats antimicrobial resistance in vulnerable populations.

Keywords:
antimicrobial stewardshipgeriatricmental healthpharmacist

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Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing
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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing
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Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Geriatric Psychiatry

Background:

  • Antimicrobial resistance poses a significant public health threat.
  • Antimicrobial stewardship programs are crucial for optimizing antibiotic use and patient outcomes.
  • Geriatric psychiatric units require tailored interventions due to unique patient needs.

Purpose of the Study:

  • To evaluate the impact of pharmacist-led interventions on the appropriateness of antimicrobial prescribing.
  • To assess changes in antimicrobial prescribing patterns on a geriatric psychiatric unit (GPU).

Main Methods:

  • A pre- and post-intervention study design was employed.
  • Patients aged 18+ prescribed oral antibiotics during GPU admission were included.
  • Antimicrobial appropriateness was evaluated based on indication, dose, and duration.

Main Results:

  • Pharmacist intervention led to a significant reduction in inappropriate antibiotic doses for indication (23.9% to 10.6%).
  • Inappropriate antibiotic duration decreased significantly post-intervention (32.4% to 15.8%).
  • Overall appropriate prescribing (dose, duration, indication) improved significantly (51% to 66%).

Conclusions:

  • Pharmacist intervention is effective in decreasing inappropriate antimicrobial prescribing on geriatric psychiatric units.
  • Targeted stewardship efforts can optimize antibiotic use in special populations.
  • Further research should explore interventions for appropriate drug and renal dose selection.