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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
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The Inflammatory Response in Psoriasis: a Comprehensive Review
Yaxiong Deng1, Christopher Chang2, Qianjin Lu3,4
1Department of Dermatology, Second Xiangya Hospital, Hunan Key Laboratory of Medical Epigenomics, Central South University, Changsha, Hunan, China.
Clinical Reviews in Allergy & Immunology
|March 31, 2016
Summary
Psoriasis involves complex immune system dysregulation, including T-helper 17 (Th17) cells, and epigenetic factors. Understanding these mechanisms is key to developing targeted therapies for this chronic autoimmune skin disease.
Area of Science:
- Immunology
- Dermatology
- Genetics
Background:
- Psoriasis is a chronic inflammatory autoimmune disease.
- Characterized by keratinocyte hyperproliferation and complex pathogenesis.
- Involves genetic, epigenetic, and environmental factors.
Purpose of the Study:
- To elucidate the complex pathogenesis of psoriasis.
- To identify key immune pathways and epigenetic factors involved.
- To inform the development of targeted therapies.
Main Methods:
- Review of recent studies on psoriasis pathogenesis.
- Analysis of epigenetic factors (DNA methylation, histone modification, microRNAs).
- Examination of immune cell interplay and cytokine pathways (Th17/Treg, IL-23/Th17 axis).
Main Results:
- Epigenetic dysregulation plays a significant role.
- The IL-23/Th17 axis and Th17 cell activity are critical.
- Immune cell interactions and cytokine networks amplify inflammation.
Conclusions:
- Understanding psoriasis pathogenesis is crucial for targeted treatment development.
- Current treatments manage symptoms, with biologics having side effects.
- Further research is needed for safe and effective novel therapies targeting immunological dysfunction.
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