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[Enterovirus infections and meningitis in children]

A S Shyshov1, M V Bazarova2, I A Blank2

  • 1Chumakov Institute of Poliomyelitis and Viral Encephalitis, Moscow.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|April 1, 2016
PubMed

Insights

Enterovirus infections (EVI) in children can cause meningitis with varied cerebrospinal fluid (CSF) changes. This study details clinical and CSF findings, aiding in diagnosis and classification for future medical coding.

Area of Science:

  • Virology
  • Pediatrics
  • Neurology

Background:

  • Enterovirus infections (EVI) are common in children.
  • Meningitis is a serious complication of EVI.
  • Understanding clinical and CSF characteristics is crucial for diagnosis and management.

Purpose of the Study:

  • To compare clinical characteristics of EVI with meningitis.
  • To detail laboratory-confirmed cerebrospinal fluid (CSF) changes in pediatric EVI patients.
  • To inform potential updates to the International Classification of Diseases (ICD-11).

Main Methods:

  • Analysis of 97 pediatric patients with EVI.
  • Detection of enterovirus RNA in feces and CSF using PCR.
  • Comparison of clinical symptoms and CSF parameters (pleocytosis, cell predominance).

Main Results:

  • Enterovirus RNA detected in CSF of 44 children; 3 showed mild cytosis.
  • Detailed presentation of symptoms in patients with and without meningitis.
  • CSF pleocytosis varied, with some cases showing neutrophil predominance and leukocytosis in peripheral blood.

Conclusions:

  • EVI presents with diverse clinical manifestations, including meningitis.
  • CSF analysis is key to diagnosing EVI-related meningitis.
  • The study supports adding 'Enterovirus infections' to ICD-11 for better classification.
Abstract

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