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Updated: Mar 23, 2026
Bilateral Common Carotid Artery Occlusion as an Adequate Preconditioning Stimulus to Induce Early Ischemic Tolerance to Focal Cerebral Ischemia
Published on: May 9, 2013
[The efficacy of pharmacological preconditioning in carotid endarterectomy]
M P Kuznetsov1, A I Fedin1, A V Karalkin2
1Pirogov Russian National Research Medical University, Moscow.
Objective:
To assess the efficacy of pharmacological preconditioning with actovegin in carotid endarterectomy.
Material And Methods:
The study was based on the results of surgical treatment of 80 patients with hemodynamically significant uni- and bilateral lesions of carotid arteries. Half of the patients was operated immediately and others after pharmacological preconditioning with actovegin in dose of 1200 mg/daily during 1,5 months.
Results:
Pharmacological preconditioning with actovegin increased the cerebral perfusion determined with one-photon emission computed tomography that improved significantly results of the surgery. There were significant changes in patient's state 7 days and 6 months after surgery. The improvement was correlated with the less number of asymptotic post-surgery ischemic strokes in different brain areas.
Conclusion:
A positive role of pharmacological preconditioning with actovegin in surgical treatment of carotid artery stenosis has been demonstrated.
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