Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Cells and Tissue01:30

Bone Cells and Tissue

10.8K
Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
10.8K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

4.7K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
4.7K
Compact Bone01:27

Compact Bone

19.6K
Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
19.6K
Bone Remodeling01:40

Bone Remodeling

41.0K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
41.0K
The Bone Matrix01:18

The Bone Matrix

7.7K
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
7.7K
Bone as Supporting Connective Tissue01:23

Bone as Supporting Connective Tissue

7.9K
Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts—...
7.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Precise Measurement of the Chromoelectric Dipole Moment of the Charm Quark.

Physical review letters·2026
Same author

First Measurement of the D_{s}^{+}→K^{0}μ^{+}ν_{μ} Decay.

Physical review letters·2026
Same author

Observation of the Electromagnetic Radiative Decays of the Λ(1520) and Λ(1690) to γΣ^{0}.

Physical review letters·2026
Same author

Discoidin Domain Receptor 2 Is Required for Tooth Extraction Socket Healing.

Journal of dental research·2026
Same author

Study of the Magnetic Dipole Transition of J/ψ→γη_{c} via η_{c}→pp[over ¯].

Physical review letters·2026
Same author

Observation of the Singly Cabibbo Suppressed Decay D^{0}→b_{1}(1235)^{-}e^{+}ν_{e} and Evidence for D^{+}→b_{1}(1235)^{0}e^{+}ν_{e}.

Physical review letters·2026

Related Experiment Video

Updated: Mar 23, 2026

Application of Retinoic Acid to Obtain Osteocytes Cultures from Primary Mouse Osteoblasts
07:13

Application of Retinoic Acid to Obtain Osteocytes Cultures from Primary Mouse Osteoblasts

Published on: May 13, 2014

14.0K

The Cementocyte-An Osteocyte Relative?

N Zhao1, B L Foster2, L F Bonewald3

  • 1Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Kansas City, MO, USA Department of Orthodontics, Shanghai Key Laboratory of Stomatology, Shanghai No. 9 Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Journal of Dental Research
|April 1, 2016
PubMed
Summary

Cementocytes, embedded cells in tooth cementum, have largely unknown functions. This review compares them to osteocytes, highlighting key research questions about their development and roles in tooth biology.

Keywords:
bonecementoblastscementumextracellular matrixodontogenesisperiodontium

More Related Videos

IDG-SW3 Cell Culture in a Three-Dimensional Extracellular Matrix
10:48

IDG-SW3 Cell Culture in a Three-Dimensional Extracellular Matrix

Published on: November 13, 2023

1.7K
Obtaining Primary Osteocytes Through Murine Calvarial Fractionation of GFP-Expressing Osteocytes
07:22

Obtaining Primary Osteocytes Through Murine Calvarial Fractionation of GFP-Expressing Osteocytes

Published on: June 2, 2020

2.7K

Related Experiment Videos

Last Updated: Mar 23, 2026

Application of Retinoic Acid to Obtain Osteocytes Cultures from Primary Mouse Osteoblasts
07:13

Application of Retinoic Acid to Obtain Osteocytes Cultures from Primary Mouse Osteoblasts

Published on: May 13, 2014

14.0K
IDG-SW3 Cell Culture in a Three-Dimensional Extracellular Matrix
10:48

IDG-SW3 Cell Culture in a Three-Dimensional Extracellular Matrix

Published on: November 13, 2023

1.7K
Obtaining Primary Osteocytes Through Murine Calvarial Fractionation of GFP-Expressing Osteocytes
07:22

Obtaining Primary Osteocytes Through Murine Calvarial Fractionation of GFP-Expressing Osteocytes

Published on: June 2, 2020

2.7K

Area of Science:

  • Dental Biology
  • Cell Biology
  • Mineralized Tissue Research

Background:

  • Cementum is a mineralized tissue crucial for tooth attachment and positional adjustment.
  • Cementocytes originate from embedded cementoblasts within the cementoid matrix.
  • These cells are terminally differentiated, similar to osteocytes and odontoblasts.

Purpose of the Study:

  • To review and synthesize current literature on cementocytes.
  • To compare cementocytes with osteocytes to infer potential functions.
  • To identify critical knowledge gaps regarding cementocyte biology.

Main Methods:

  • Literature review and synthesis.
  • Comparative analysis of cementocytes and osteocytes.
  • Identification of research questions based on existing data.

Main Results:

  • Cementocyte differentiation and function remain largely uncharacterized.
  • The morphology and lacuno-canalicular system of cementocytes require further investigation.
  • Potential roles in cementum metabolism and response to physiological signals are unknown.

Conclusions:

  • Significant research is needed to understand cementocyte origins, differentiation, and morphology.
  • Further studies are essential to elucidate the functional significance of cementocytes in cementum.
  • Comparative studies with osteocytes offer a valuable framework for future cementocyte research.