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S-Nitrosothiols as Platforms for Topical Nitric Oxide Delivery
Marcelo Ganzarolli de Oliveira1
1Physical-Chemistry Department, Institute of Chemistry, University of Campinas, UNICAMP, Campinas, SP, Brazil. mgo@iqm.unicamp.br.
Basic & Clinical Pharmacology & Toxicology
|April 1, 2016
Summary
S-nitrosothiols (RSNOs) offer localized nitric oxide (NO) delivery for non-cardiovascular therapies. Topical formulations using RSNOs show promise in wound healing, antimicrobial action, and pain relief.
Area of Science:
- Biochemistry
- Pharmacology
- Materials Science
Background:
- Nitric oxide (NO) is crucial for physiological processes like vascular tone and immune response.
- Endothelial dysfunction and reduced NO bioavailability contribute to various diseases.
- Systemic NO donors treat hypertension, but local NO delivery is needed for other applications.
Purpose of the Study:
- To review the current state of experimental topical formulations for localized nitric oxide (NO) delivery.
- To explore the therapeutic potential of S-nitrosothiols (RSNOs) in non-cardiovascular applications.
Main Methods:
- Review of literature on S-nitrosothiols (RSNOs) as NO carriers and donors.
- Analysis of topical formulation strategies, including low molecular weight and polymeric RSNOs.
- Evaluation of biological actions reported for these NO-delivery systems.
Main Results:
- S-nitrosothiols (RSNOs) are effective platforms for localized NO delivery in topical applications.
- Formulations range from incorporated RSNOs in vehicles to covalently bound polymeric RSNOs.
- Demonstrated biological effects include dermal vasodilation, accelerated wound healing, antimicrobial activity, and analgesia.
Conclusions:
- Topical RSNO formulations represent a promising strategy for localized NO therapy.
- These formulations have potential applications beyond cardiovascular conditions, targeting wound healing, infections, and pain.
- Further research into experimental topical NO delivery systems based on RSNOs is warranted.
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