[Neuroanatomical age-related changes in apathy]

Area of Science:

• Neuroscience
• Gerontology
• Psychiatry

Context:

• Advancements in neuroimaging techniques such as magnetic-resonance tomography (MRI) and one-photon emission computed tomography (OPECT) have significantly enhanced the study of neurological and mental diseases.
• Apathy is a common and debilitating symptom in older adults with various neurological and psychiatric conditions, impacting quality of life and treatment outcomes.

Purpose:

• To review and synthesize the findings from neuroimaging studies investigating the neuroanatomical and functional correlates of late-life apathy.
• To provide an overview of the current understanding of brain mechanisms underlying apathy in the context of diverse geriatric clinical syndromes.

Summary:

• This review consolidates evidence from magnetic-resonance tomography (MRI) and one-photon emission computed tomography (OPECT) studies published over the last two decades.
• Key neuroanatomical and functional brain alterations associated with apathy in elderly individuals suffering from neurological and mental diseases are identified and discussed.

Impact:

• The findings contribute to a better understanding of the neurobiological underpinnings of apathy in old age.
• This summary can inform future research directions and clinical diagnostic and therapeutic strategies for apathy in geriatric populations.