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Acetazolamide polymorphism: a case of hybridization induced polymorphism?

Sounak Sarkar1, Mysore S Pavan, Suryanarayan Cherukuvada

  • 1Solid State and Structural Chemistry Unit, Indian Institute of Science, Bangalore 560 012, India. ssctng@sscu.iisc.ernet.in.

Chemical Communications (Cambridge, England)
|April 2, 2016
PubMed
Summary

Acetazolamide, a diuretic drug, forms a kinetic crystal structure instead of the expected thermodynamic form when its boiling aqueous solution cools slowly. This phenomenon is explained by "hybridization induced polymorphism," supported by experimental and theoretical data.

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