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T1 Signal-Intensity Increase in the Dentate Nucleus after Multiple Exposures to Gadodiamide: Intraindividual
J Ramalho1, M Ramalho2, M AlObaidy3
1From the Department of Radiology (J.R., M.R., M.A., R.H.N., M.C., R.C.S.), University of North Carolina at Chapel Hill, Chapel Hill, North Carolina Department of Neuroradiology (J.R.), Centro Hospitalar de Lisboa Central, Lisbon, Portugal Joana-Ramalho@netcabo.pt.
AJNR. American Journal of Neuroradiology
|April 2, 2016
Summary
Different MRI sequences show varying gadolinium deposition in the dentate nucleus. MPRAGE sequences offer better correlation for qualitative and quantitative analysis compared to spin-echo sequences.
Area of Science:
- Radiology
- Neuroimaging
- Medical Physics
Background:
- Gadolinium-based contrast agents (GBCAs) can lead to deposition in the brain, particularly the dentate nucleus.
- T1-weighted MRI sequences are used to assess signal intensity changes related to gadolinium deposition.
- Multiple GBCAs administrations raise concerns about long-term effects and reliable imaging assessment.
Purpose of the Study:
- To compare T1-weighted spin-echo (SE) and 3D magnetization-prepared rapid acquisition of gradient echo (MPRAGE) sequences.
- To evaluate intraindividual qualitative and quantitative differences in assessing gadolinium deposition in the dentate nucleus.
- To determine if these sequences are interchangeable for analyzing signal intensity changes over time.
Main Methods:
- Retrospective analysis of 18 patients with at least 3 gadodiamide administrations.
- Comparison of baseline and final MR imaging using both SE and MPRAGE sequences.
- Qualitative and quantitative analyses of dentate nucleus/middle cerebellar peduncle signal-intensity ratios.
- Statistical comparison using Wilcoxon signed rank test and polyserial correlation.
Main Results:
- Statistically significant differences in baseline and final ratios between SE and MPRAGE sequences (P = .008, P = .006).
- No significant difference in signal-intensity changes over time for either sequence (P = .64).
- Strong correlation between qualitative and quantitative analysis: near-perfect (r = 0.9) for MPRAGE and strong (r = 0.63) for SE.
Conclusions:
- T1-weighted SE and MPRAGE sequences are not interchangeable for analyzing gadolinium deposition in the dentate nucleus.
- Consistent use of the same sequence is crucial for longitudinal assessments.
- MPRAGE sequences demonstrate superior correlation with quantitative analysis, potentially offering advantages for research.
