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ICOS Expression as Immunologic Marker in Immune Activating Monoclonal Antibodies
Riccardo Danielli1,2, Ornella Cutaia3, Carolina Fazio3
1Medical Oncology and Immunotherapy, Istituto Toscano Tumori, University Hospital of Siena, Siena, Italy. r.danielli.e@ao-siena.toscana.it.
Abstract:
Compelling experimental evidences point to monitoring of the absolute number of circulating ICOS-positive T cells as an early predictive marker of clinical activity of anti-CTLA-4 antibodies in cancer patients. Here, we report available data focusing on this issue and operative procedures to detect ICOS expression on circulating peripheral blood mononuclear cells during CTLA-4 blockade therapy.
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