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Intestinal transplantation in children: current status
Andrea Martinez Rivera1,2, Paul W Wales3,4
1Group for the Improvement of Intestinal Failure and Treatment (GIFT), The Hospital for Sick Children, University of Toronto, Toronto, Canada.
Pediatric Surgery International
|April 2, 2016
Summary
Intestinal transplantation has improved significantly, with 76% survival at 1 year, thanks to surgical advances and better immunosuppression. Challenges like chronic rejection remain, but it offers hope for intestinal failure patients.
Area of Science:
- Gastroenterology and Hepatology
- Transplant Surgery
- Immunology
Background:
- Intestinal transplantation (IT) is a rare but growing field.
- Significant advancements in surgical techniques and immunosuppressive therapies have improved outcomes.
- Improved understanding of recipient-host immune interactions is key.
Purpose of the Study:
- To review the current status of intestinal transplantation.
- To outline the indications for IT.
- To discuss outcomes and recent advances in the field.
Main Methods:
- Review of current literature on intestinal transplantation.
- Analysis of graft survival rates and patient outcomes.
- Discussion of evolving immunosuppressive strategies and surgical techniques.
Main Results:
- First-year graft survival rates have reached 76%.
- Improvements are attributed to surgical refinements and enhanced immunosuppression.
- Chronic rejection and long-term survival remain challenges.
Conclusions:
- Intestinal transplantation is a viable option for select patients with intestinal failure.
- It is reserved for those with severe complications or poor quality of life despite conventional treatments.
- Ongoing research focuses on overcoming long-term rejection and improving survival rates.
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