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Rickettsia massiliae infection and SENLAT syndrome in Romania
Mihaela Zaharia1, Corneliu Petru Popescu2, Simin Aysel Florescu2
1Dr. Victor Babes Clinical Hospital for Infectious and Tropical Diseases, Bucharest, Romania.
Abstract:
The purpose of this prospective study is to describe the clinical and epidemiological characteristics of rickettsioses in Romania, where only Rickettsia conorii is known by clinicians but new Rickettsia species have been identified recently in ticks. A total of eight patients, including a nine-year-old child, were included between June 2011 and June 2012, in the Hospital for Infectious and Tropical Diseases, Bucharest, Romania. Seven cases presented during summer months and one in spring. Six patients presented a generalized rash with fever, myalgia and skin eschar. The last two patients presented a typical SENLAT syndrome, characterized by scalp eschar and neck lymphadenopathy. Using serological tools, we confirmed for the first time two cases of Rickettsia massiliae, the agent of spotted fever disease, and one case of Rickettsia slovaca, and one case of R. slovacaRickettsia raoultii the agents of SENLAT syndrome.
Insights
This study identified new tick-borne Rickettsia species causing spotted fever and SENLAT syndrome in Romania. These findings expand the known spectrum of rickettsioses in the region.
Area of Science:
- Infectious Diseases
- Epidemiology
- Microbiology
Background:
- Rickettsioses are emerging tick-borne diseases with diverse clinical presentations.
- Romania historically recognized Rickettsia conorii, but recent tick surveillance indicated other species.
- This study aimed to characterize rickettsioses in Romania, focusing on novel Rickettsia species.
Discussion:
- The study highlights the presence of Rickettsia massiliae and Rickettsia slovaca/Rickettsia raoultii in Romania.
- Clinical manifestations included classic spotted fever symptoms and Scalp Eschar and Neck LYmphadenopathy After Tick bites (SENLAT) syndrome.
- Early diagnosis and appropriate treatment are crucial for managing rickettsioses.
Key Insights:
- First confirmation of Rickettsia massiliae causing spotted fever in Romania.
- Identification of Rickettsia slovaca and R. slovaca/R. raoultii associated with SENLAT syndrome.
- Clinical and epidemiological data provide insights into rickettsioses burden in Romania.
Outlook:
- Further research is needed to understand the prevalence and geographic distribution of these Rickettsia species in Romania.
- Enhanced diagnostic capabilities and public awareness are essential for controlling tick-borne diseases.
- This study contributes to a better understanding of tick-borne rickettsioses in Eastern Europe.
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