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Published on: September 12, 2019
Transgenic Mouse Models of SV40-Induced Cancer
Amanda L Hudson1, Emily K Colvin1
1Amanda L. Hudson, PhD, is a Sydney Neuro-Oncology Group postdoctoral fellow at the Bill Walsh Translational Cancer Research Laboratory, Kolling Institute, Northern Sydney Local Health District, Sydney Medical School Northern, University of Sydney, St. Leonards, NSW, Australia. Emily K. Colvin is a Cancer Institute NSW postdoctoral fellow at the Bill Walsh Translational Cancer Research Laboratory, Kolling Institute, Northern Sydney Local Health District, Sydney Medical School Northern, University of Sydney, St. Leonards, NSW, Australia.
Abstract:
The SV40 viral oncogene has been used since the 1970s as a reliable and reproducible method to generate transgenic mouse models. This seminal discovery has taught us an immense amount about how tumorigenesis occurs, and its success has led to the evolution of many mouse models of cancer. Despite the development of more modern and targeted approaches for developing genetically engineered mouse models of cancer, SV40-induced mouse models still remain frequently used today. This review discusses a number of cancer types in which SV40 mouse models of cancer have been developed and highlights their relevance and importance to preclinical research.
Insights
The Simian vacuolating virus (SV40) oncogene remains a valuable tool for creating cancer mouse models. These models are crucial for understanding tumorigenesis and advancing preclinical cancer research.
Area of Science:
- Oncology
- Virology
- Genetics
Background:
- The Simian vacuolating virus (SV40) viral oncogene has been instrumental in cancer research since the 1970s.
- Its application has facilitated the development of numerous transgenic mouse models for studying tumorigenesis.
- Despite advancements in genetic engineering, SV40-induced models persist in their utility.
Purpose of the Study:
- To review the application of SV40-induced mouse models across various cancer types.
- To highlight the ongoing relevance and significance of these models in preclinical research.
- To underscore the historical and continued importance of SV40 in cancer modeling.
Main Methods:
- Review of existing literature on SV40-induced mouse models of cancer.
- Analysis of the types of cancers studied using these models.
- Evaluation of the contribution of SV40 models to preclinical research findings.
Main Results:
- SV40 has been successfully employed to create reproducible transgenic mouse models for a range of cancers.
- These models have significantly contributed to the understanding of cancer development and progression.
- SV40-induced models continue to be relevant for investigating novel cancer therapies.
Conclusions:
- SV40-induced mouse models represent a foundational and enduring methodology in cancer research.
- Their reliability and reproducibility make them indispensable for studying diverse oncogenic processes.
- These models remain critical for advancing preclinical research and therapeutic development in oncology.
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