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Sperm is epigenetically programmed to regulate gene transcription in embryos

Marta Teperek1, Angela Simeone1, Vincent Gaggioli1

  • 1Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, CB2 1QN, United Kingdom; Department of Zoology, University of Cambridge, Cambridge, CB2 3EJ, United Kingdom;

Genome Research
|April 2, 2016
PubMed
Summary

Sperm epigenetics influence embryonic gene expression. Specific epigenetic marks (H3K27me3) on sperm DNA are crucial for regulating key developmental genes, demonstrating a paternal role in offspring development.

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