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A protein-protein interaction is essential for stable complex formation on a 5 S RNA gene
J Hayes1, T D Tullius, A P Wolffe
1Department of Chemistry, Johns Hopkins University, Baltimore, Maryland 21218.
The Journal of Biological Chemistry
|April 15, 1989
Abstract:
Stable complex formation on a Xenopus somatic 5 S RNA gene requires protein-protein interactions between the non-DNA binding domain of transcription factor (TF) IIIA and activities in a TFIIIC fraction. No significant changes in the structure of the TFIIIA.DNA complex can be detected as a consequence of stabilization, indicating that protein confirmation is the primary determinant of stability.