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Related Experiment Video

Updated: Mar 23, 2026

Manufacture of Concentrated, Lipid-based Oxygen Microbubble Emulsions by High Shear Homogenization and Serial Concentration

Manufacture of Concentrated, Lipid-based Oxygen Microbubble Emulsions by High Shear Homogenization and Serial Concentration

Published on: May 26, 2014

High Yielding Microbubble Production Method.

Joe Fiabane¹, Paul Prentice², Ketan Pancholi¹

¹School of Engineering, The Robert Gordon University, Aberdeen AB10 7GE, UK.

Biomed Research International

|April 2, 2016

Summary

This summary is machine-generated.

This study introduces a novel method for producing microbubbles with high yield and reduced channel blockage. The technique generates 2.6 μm microbubbles at high concentrations, overcoming limitations of microfluidic approaches.

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Last Updated: Mar 23, 2026

Manufacture of Concentrated, Lipid-based Oxygen Microbubble Emulsions by High Shear Homogenization and Serial Concentration

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Published on: May 26, 2014

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Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Published on: June 12, 2021

Area of Science:

Biotechnology
Chemical Engineering
Materials Science

Background:

Microfluidic methods for microbubble generation often suffer from low production yields.
Existing techniques are prone to microchannel blockages, limiting their practical application.

Purpose of the Study:

To present an alternative, high-yield method for microbubble production.
To address the issue of channel blockages common in microfluidic systems.

Main Methods:

A coflowing nitrogen gas-liquid jet is disintegrated by surrounding air passing through a 100 μm orifice at high velocity.
This process generates a spray of microbubbles, forming a microbubble foam.

Main Results:

Achieved production of microbubbles with a mean diameter of 2.6 μm.
Obtained high concentrations exceeding 30 × 10^6 mL⁻¹.
Resulting microbubble foam exhibited a low polydispersity index of 16% and a mean diameter to channel width ratio < 0.025, significantly reducing blockages.

Conclusions:

The presented method offers a significant improvement over traditional microfluidic techniques for microbubble generation.
The high yield and reduced blockage potential make this method suitable for scalable applications.