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The Adenosinergic System in Diabetic Retinopathy
J Vindeirinho1, A R Santiago2, C Cavadas3
1Center for Neuroscience and Cell Biology (CNC), University of Coimbra, 3004-504 Coimbra, Portugal; Institute for Interdisciplinary Research (III), University of Coimbra, 3030-789 Coimbra, Portugal; CNC.IBILI, University of Coimbra, 3004-504 Coimbra, Portugal.
Journal of Diabetes Research
|April 2, 2016
Summary
Diabetic retinopathy involves inflammation and neurodegeneration. The adenosinergic system, with its four receptors, is affected by diabetes and may offer therapeutic targets for early-stage diabetic eye disease.
Area of Science:
- Ophthalmology
- Neuroscience
- Endocrinology
Background:
- Diabetic retinopathy is characterized by a neuroinflammatory environment in the eye.
- The adenosinergic system modulates neurotransmission and inflammation via adenosine receptors (A1R, A2AR, A2BR, A3R).
Purpose of the Study:
- To review the impact of diabetic conditions on the retinal adenosinergic system.
- To explore the role of the adenosinergic system in diabetic retinopathy development and progression.
Main Methods:
- Literature review of studies investigating the retinal adenosinergic system in diabetic conditions.
- Analysis of experimental results on the modulation of adenosine receptors in diabetic retinopathy models.
Main Results:
- Diabetic conditions significantly alter the retinal adenosinergic system.
- Evidence suggests the adenosinergic system plays a role in both exacerbating and ameliorating diabetic retinopathy.
Conclusions:
- The adenosinergic system is a key factor in the early stages of diabetic retinopathy.
- Modulating components of the adenosinergic system presents potential therapeutic strategies for diabetic eye disease.
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