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[Adult-onset opsoclonus-myoclonus-ataxia syndrome revealing rubella meningoencephalitis]

A Nasri1, M Mansour1, M Messelmani1

  • 1Service de neurologie, hôpital militaire principal d'instruction de Tunis, Tunis, Tunisie.

La Revue De Medecine Interne
|April 3, 2016
PubMed
Abstract

Insights

Rubella virus infection can cause Opsoclonus-myoclonus-ataxia (OMS) syndrome, a rare neurological disorder. This case report details a young man’s full recovery with acyclovir treatment, expanding known causes of OMS.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Virology

Background:

  • Opsoclonus-myoclonus-ataxia (OMS) is a rare neurological syndrome.
  • It can arise from various causes including paraneoplastic, infectious, or idiopathic origins.

Observation:

  • A 24-year-old male presented with gait disorder, rash, lymphadenopathy, and subsequent opsoclonus-myoclonus-ataxia syndrome.
  • Initial investigations including MRI, MIBG scintigraphy, and tumor markers were normal.
  • Cerebrospinal fluid analysis revealed lymphocytic meningitis.

Findings:

  • Serum and CSF IgM antibodies against rubella virus were positive.
  • The patient received acyclovir and experienced a complete recovery within two weeks.

Implications:

  • This case expands the known neurological manifestations of rubella virus.
  • It highlights rubella as a potential infectious etiology for Opsoclonus-myoclonus-ataxia syndrome.
Keywords:
AdultAdulteKinsbourneMeningoencephalitisMéningo-encéphaliteOpsoclonus-myoclonusRubellaRubéole

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