The impact of exercise-induced core body temperature elevations on coagulation responses
Matthijs T W Veltmeijer1, Thijs M H Eijsvogels2, Wideke Barteling3
1Radboud University Medical Center, Radboud Institute for Health Sciences, Department of Physiology, The Netherlands.
Journal of Science and Medicine in Sport
|April 3, 2016
Summary
Exercise increases core body temperature (CBT), leading to a pro-thrombotic state. The magnitude of CBT rise influences this effect, highlighting the importance of accurate temperature measurements in assessing haemostasis.
Area of Science:
- Physiology
- Exercise Science
- Haemostasis Research
Background:
- Exercise significantly impacts physiological parameters, including core body temperature (CBT) and haemostatic function.
- Understanding the relationship between elevated CBT and thrombotic risk is crucial for interpreting exercise-related physiological changes.
Purpose of the Study:
- To investigate whether exercise-induced increases in CBT promote pro-thrombotic changes in a dose-dependent manner.
- To assess the influence of accurate core body temperature measurement on haemostatic assays.
Main Methods:
- An observational study involving 62 participants in a 15-km road race.
- Core body temperature and haemostatic responses were measured at baseline and post-race.
- Haemostasis assays were adjusted to individual CBT in a subgroup (n=25) to account for temperature variations.
Main Results:
- Participants experienced a significant increase in CBT from 37.6°C to 39.4°C post-exercise (p<0.001).
- Post-exercise, increased haemostatic activity was observed, characterized by accelerated thrombin generation and reduced plasmin response.
- Adjusting assay temperature to individual CBT revealed stronger pro-thrombotic effects.
Conclusions:
- Exercise induces a pro-thrombotic state, potentially linked to the extent of CBT elevation.
- Accurate temperature correction in haemostasis assays is vital for understanding haemostatic balance during thermoregulatory stress.
- Short exposure to high CBT (41.2°C) did not cause severe coagulation issues, suggesting a threshold effect for haemostatic derangement.
Related Concept Videos
01:20Exercise and Cardiovascular Response
4.9K
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
4.9K
01:28Factors Affecting Body Temperature
9.9K
As a nurse, it is vital to understand the factors affecting body temperature to monitor variations and effectively evaluate deviations from regular.
Factors may include:
Factors may include:
9.9K
02:45Responses to Heat and Cold Stress
15.6K
Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.
15.6K
01:19Assessing Body Temperature - Temporal Artery
1.5K
Here is a stepwise guide to assessing the body temperature at the temporal artery using a temporal artery thermometer
Step 1: Perform hand hygiene and don a fresh pair of gloves to prevent cross-infection and ensure patient safety.
Step 2: Explain the procedure to the patient to establish trust. Clear communication establishes trust with the patient, ensures they understand what to expect, promotes cooperation, and enhances comfort during the procedure.
Step 3: Assess the patient's...
Step 1: Perform hand hygiene and don a fresh pair of gloves to prevent cross-infection and ensure patient safety.
Step 2: Explain the procedure to the patient to establish trust. Clear communication establishes trust with the patient, ensures they understand what to expect, promotes cooperation, and enhances comfort during the procedure.
Step 3: Assess the patient's...
1.5K
01:25Increased Body Temperature
7.6K
A body temperature above 38°C (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
7.6K
01:26Thermoregulation
3.0K
The human body has a sophisticated thermoregulation system that employs negative feedback mechanisms to maintain an optimal core temperature. When the core temperature drops, peripheral and central thermoreceptors send signals to the hypothalamus, activating the heat-promoting center. This center triggers several responses aimed at increasing the core temperature. First, vasoconstriction reduces the flow of warm blood from internal organs to the skin so that the heat is not lost from the skin,...
3.0K