Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Allergic Reactions: Anaphylaxis

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...

Allergic Reactions

Allergic Reactions

Asthma: Pathogenesis and Management

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

Allergic Drug Reactions

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...

Cross-reactivity

Cross-reactivity

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Alpha-gal Immunoglobulin E Seroprevalence Among Blood Donors - 10 States, 2024-2025.

MMWR. Morbidity and mortality weekly report·2026

Same author

CRISPR-mediated engineering of bovine satellite cells for Alpha-Gal Syndrome-compatible cultivated meat.

bioRxiv : the preprint server for biology·2026

Same author

Irradiation does not impact the immunogenicity of food flours used for oral immunotherapy.

The journal of allergy and clinical immunology. Global·2026

Same author

Early-life peanut oral immunotherapy associated with long-term ingestion and immunologic changes.

The Journal of allergy and clinical immunology·2026

Same author

Biologics and Novel Therapeutics in Food Allergy.

The journal of allergy and clinical immunology. In practice·2026

Same author

Legends of Allergy & Immunology: A. Wesley Burks: Advocate for Children's Health Through Scientific Discovery.

Allergy·2026

Same journal

Harnessing Machine Learning and Electronic Health Record Data to Improve Asthma Management.

Current allergy and asthma reports·2026

Same journal

Incorporating New Guidelines into School-Based Asthma Management.

Current allergy and asthma reports·2026

Same journal

The Modern Environment and Childhood Asthma: The Role of Air Pollution and Heavy Metal Exposure.

Current allergy and asthma reports·2026

Same journal

Targeting Type 2 and Non-type 2 Asthma: Emerging Biologics and Personalized Strategies.

Current allergy and asthma reports·2026

Same journal

The Role of the Indoor Exposome in Food Allergy Development.

Current allergy and asthma reports·2026

Same journal

Understanding Infantile Atopic Dermatitis: A Review of Environmental, Familial, Genetic and Microbial Influences.

Current allergy and asthma reports·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 23, 2026

Basophil Activation Test for Allergy Diagnosis

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Peanut Allergy: New Developments and Clinical Implications.

Scott P Commins^1,2,3,4, Edwin H Kim^5,6,7, Kelly Orgel⁷

¹Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA. scommins@email.unc.edu.

Current Allergy and Asthma Reports

|April 4, 2016

Summary

This summary is machine-generated.

Food allergies are a growing public health issue. Investigational immunotherapies, including oral and sublingual immunotherapy, show promise for desensitizing patients with peanut, egg, and milk allergies.

Keywords:

Anaphylaxis Food allergy IgE Peanut allergy

More Related Videos

Antigenic Liposomes for Generation of Disease-specific Antibodies

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

Related Experiment Videos

Last Updated: Mar 23, 2026

Basophil Activation Test for Allergy Diagnosis

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Antigenic Liposomes for Generation of Disease-specific Antibodies

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

Area of Science:

Immunology
Allergy Research
Public Health

Background:

Food allergies have significantly increased over the last two decades.
Current clinical care lacks routine therapies for food allergies.
Emerging research suggests mucosal immunotherapies may offer effective treatment.

Purpose of the Study:

To review the complexities of immunoglobulin E (IgE)-mediated food allergies.
To discuss current diagnostic and management strategies for food allergies.
To highlight investigational therapies for food allergies currently in clinical trials.

Main Methods:

Review of existing literature on food allergy immunotherapies.
Analysis of clinical trial data for oral immunotherapy (OIT) and sublingual immunotherapy (SLIT).
Focus on desensitization strategies for common food allergens like peanut, egg, and milk.

Main Results:

Oral immunotherapy demonstrates potential for desensitizing individuals with peanut, egg, and milk allergies.
Sublingual immunotherapy has been investigated in major studies for peanut allergy desensitization.
Immunotherapies targeting the mucosal immune system show promise.

Conclusions:

IgE-mediated food allergies present a complex clinical challenge.
Investigational immunotherapies, such as OIT and SLIT, are promising therapeutic avenues.
Further research into diagnosis, management, and novel therapies is crucial for public health.