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[Magnesium: the missing link between kidneys and vessels?]

Thien-An Tran, David Jaques, Belen Ponte

    Revue Medicale Suisse
    |April 5, 2016
    PubMed

    Insights

    Low magnesium levels (hypomagnesemia) may worsen outcomes for patients with chronic kidney disease (CKD) and cardiovascular disease. Maintaining adequate magnesium may offer protection, but more research is needed.

    Area of Science:

    • Nephrology
    • Cardiology
    • Mineral Metabolism

    Context:

    • Chronic kidney disease (CKD) is a global health concern with significant cardiovascular implications.
    • Cardiovascular morbidity and mortality are high in CKD patients.
    • Magnesium's role in CKD and cardiovascular outcomes is under-explored.

    Purpose:

    • To review recent studies on the association between magnesium levels, cardiovascular disease, and CKD.
    • To evaluate the potential prognostic and therapeutic significance of magnesium in CKD.

    Summary:

    • Observational data suggest that low magnesium levels (hypomagnesemia) are linked to poorer cardiovascular and renal prognosis in CKD.
    • Maintaining normal magnesium levels might be protective against adverse outcomes.
    • Current evidence is primarily from observational studies with heterogeneous populations, limiting definitive conclusions.

    Impact:

    • Highlights the potential importance of magnesium in managing CKD and cardiovascular risk.
    • Identifies the need for further research, including controlled trials, to establish therapeutic recommendations.
    • Suggests magnesium status as a potential area for future investigation in CKD management.

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