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Oxcarbazepine-induced liver injury after sensitization by valproic acid: a case report
Alanna Chait Mermelstein1, Joseph Mermelstein2, Tarek Adam1
1Department of Psychiatry, New York Presbyterian Hospital/Weill Cornell Medicine, New York, NY, USA.
Objective:
The aim of the present case report is to describe a potential interaction between valproic acid and oxcarbazepine that resulted in hepatic injury.
Methods:
We report the case of a 46-year-old man with schizoaffective disorder who was cross-titrated from valproic acid to oxcarbazepine because of liver injury.
Results:
Initiation of oxcarbazepine four days after stopping valproic acid produced a significant elevation in liver enzymes that normalized with oxcarbazepine discontinuation and did not reappear with its reintroduction five days later.
Conclusions:
Our findings suggest that a longer washout period or another agent should be considered when transitioning from valproic acid to oxcarbazepine.
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