[Principles of treating blood coagulation disorders in patients with obstructive jaundice]

Activation of blood anticoagulative potential, fibrinolysis in particular, facilitates the development of hemorrhagic complications of obstructive jaundice. Increase of blood platelet adhesion and fibrinogen concentration and reduction of fibrinolysis are evidence of the risk of occurrence of thrombotic complications in the postoperative period. Changes in the findings of laboratory tests for blood coagulation precede the appearance of clinical signs of complications as a rule. The use of protease inhibitors in hemorrhages is an essential supplement to the scope of measures of hemostatic therapy and increases its efficacy significantly. This method was used for treating 28 patients with hemorrhagic complications of jaundice among 96 patients suffering from hemocoagulation disorders caused by prolonged obstruction of the bile tract.