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Published on: May 1, 2019
Immunohistochemical study of gastrin in colorectal carcinoma tissues and adjacent mucosa
C P Jiang1, Y Q Chen1, J W Zhu1
1Chun-Ping Jiang, Yu-Quan Chen, Jian-Wei Zhu, Hong-Xun Shen, Xiu Yu, Department of General Surgery, Affiliated Hospital, Nantong Medical College, Nantong 226001, Jiangsu Province, China.
Aim:
To study gastrin expression in colorectal carcinoma tissues and adjacent mucosa and discuss the function of gastrin in colorectal carcinoma.
Methods:
Gastrin expression in colorectal carcinoma tissues and adjacent mucosa was examined in 58 cases using immunohistochemical and immunoelectron microscopy.
Results:
A total of 35.1% of colorectal carcinoma transitional mucosa (TM), 48.3% of nontypical dysplasia mucosa and 60.3% of carcinoma tissue were positive for gastrin expression (P < 0.05). Immunoelectron microscopy revealed that protein A gold (PAG) granules localized to different electron-dense secretory granules in carcinoma cells, the intercellular spaces, and the microvillar membrane surface.
Conclusion:
Gastrin expression in colorectal carcinoma tissue and adjacent mucosa, and the release of gastrin by carcinoma may be an initiating factor in carcinoma occurrence and development. Positive gastrin expression in colorectal carcinoma tissues can serve as a differentiation marker.
