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RhoC GTPase Activation Assay
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Regulation of Cancer Cell Behavior by the Small GTPase Rab13

Maria S Ioannou1, Peter S McPherson2

  • 1From the Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada.

The Journal of Biological Chemistry
|April 6, 2016
PubMed

Insights

Rab13 GTPases are key regulators of cellular membrane trafficking. This review highlights Rab13

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Cancer Biology

Background:

  • Rab GTPases are crucial regulators of intracellular membrane trafficking.
  • Aberrant membrane trafficking is linked to various diseases, including cancer.
  • The Rab family comprises approximately 70 human members involved in diverse cellular processes.

Purpose of the Study:

  • To review the role of Rab13 in cellular membrane trafficking.
  • To highlight the involvement of Rab13 in cancer progression.
  • To consolidate evidence on Rab13 as a driver of oncogenesis.

Main Methods:

  • Literature review of studies on Rab GTPases and cancer.
  • Analysis of experimental data implicating Rab13 in cellular functions.
  • Synthesis of findings on Rab13's role in cancer progression.

Main Results:

  • Rab13 plays a significant role in multiple stages of membrane trafficking.
  • Evidence suggests Rab13 influences key cellular processes like migration and adhesion.
  • Rab13 is implicated as a potent driver of cancer progression.

Conclusions:

  • Rab13 is a critical regulator of membrane trafficking with implications in cancer.
  • Dysregulation of Rab13 contributes to cancer development and progression.
  • Targeting Rab13 may offer therapeutic strategies for cancer treatment.
Keywords:
DENNRabRab13actincancercell adhesioncell migrationguanine nucleotide exchange factor (GEF)integrinmical

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