Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A mathematical procedure for estimating the spatial relationships between lung function, somatic growth, and

D L Sherrill1, W J Morgan, L M Taussig

  • 1Westend Research Laboratory, University of Arizona College of Medicine, Tucson 85724.

Pediatric Research
|March 1, 1989
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Single breath nitrogen test as predictor of lung function decline and COPD over an 8-year follow-up.

Pulmonology·2022
Same author

Trust in scientific information mediates associations between conservatism and coronavirus responses in the U.S., but few other nations.

Scientific reports·2022
Same author

Pulmonary disease.

Postgraduate medicine·2016
Same author

Physiotherapy and lung disease in children.

The Australian journal of physiotherapy·2014
Same author

Can a management pathway for chronic cough in children improve clinical outcomes: protocol for a multicentre evaluation.

Trials·2010
Same author

Prospective audit of cross-sectional imaging and radiation exposure in general surgical patients.

Annals of the Royal College of Surgeons of England·2010

This study introduces a mathematical method to analyze lung function (FEV1) growth velocity in children. The findings reveal how lung function growth aligns with physical growth and maturation, offering insights into respiratory development.

Area of Science:

  • Pulmonary Medicine
  • Biostatistics
  • Pediatric Respiratory Research

Background:

  • Assessing lung function growth velocity in children is crucial for understanding respiratory development.
  • Existing methods may struggle with the inherent variability in pulmonary function data.
  • Relating lung function changes to somatic growth and maturation requires robust analytical techniques.

Purpose of the Study:

  • To describe a novel mathematical procedure for analyzing lung function (FEV1) growth velocity in relation to somatic growth and maturation.
  • To apply and validate this procedure using data from a large cohort of healthy children and adolescents.
  • To investigate the temporal relationships between the peaks of somatic growth, lung function growth, and maturation.

Main Methods:

Related Experiment Videos

  • Utilized a polynomial smoothing spline model to fit curves to pulmonary function data.
  • Estimated the first derivatives of these curves to represent growth velocity.
  • Applied the method to data from the Tucson Epidemiological Study of Airway Obstructive Diseases (772 healthy subjects, ages 3-25).

    • Main Results:

    • The peak growth velocity of somatic growth precedes the peak growth velocity of FEV1 by approximately 7 months in females and 11 months in males.
    • The peak growth velocity of maturation lags behind the peak FEV1 growth velocity by about 1 year in both sexes.
    • The FEV1/FVC ratio showed minimal growth velocity, suggesting FEV1 growth is driven by lung volumes rather than expiratory flow rates alone.

    Conclusions:

    • The polynomial smoothing spline procedure effectively models noisy pulmonary function data.
    • This method accurately estimates growth velocity curves for lung function parameters.
    • The findings provide a detailed timeline of respiratory system development relative to overall growth and maturation in children and adolescents.