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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
Dengue tropism for macrophages and dendritic cells: the host cell effect
Jacky Flipse1, Silvia Torres1,2, Mayra Diosa-Toro1,2
1Department of Medical Microbiology, University Medical Center Groningen, University of Groningen, The Netherlands.
Abstract:
Dengue virus infects immune cells, including monocytes, macrophages and dendritic cells (DC). We compared virus infectivity in macrophages and DC, and found that the virus origin determined the cell tropism of progeny virus. The highest efficiency of re-infection was seen for macrophage-derived dengue virus. Furthermore, in the presence of enhancing antibodies, macrophage-derived virus gave greater enhancement of infection compared with immature DC-derived virus. Taken together, our results highlight the importance of macrophages in dengue infection.
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