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Related Concept Videos

Chemical Synapses01:26

Chemical Synapses

7.9K
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
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Chemical Synapses01:26

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Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
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Postsynaptic Potential (PSP)01:32

Postsynaptic Potential (PSP)

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Postsynaptic potential (PSP) refers to a change in the electrical potential of a neuron when neurotransmitters released by presynaptic neurons bind to postsynaptic receptors. This potential can either be excitatory, leading to depolarization and ultimately action potential generation, or inhibitory, leading to hyperpolarization and suppression of the postsynaptic neuron.
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Fusion of Secretory Vesicles with the Plasma Membrane01:26

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Proteins and neurotransmitters in secretory vesicles can be released from a cell upon vesicle docking, priming, and fusion with the plasma membrane. Vesicles are docked and primed in preparation for the quick exocytosis of their contents in response to a stimulus. The fusion process is mainly carried out by a SNAP Receptor or SNARE complex, consisting of synaptobrevin, syntaxin-1, and SNAP-25.
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Synaptic Signaling01:09

Synaptic Signaling

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Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
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Synaptic Signaling01:12

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Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
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Related Experiment Video

Updated: Mar 23, 2026

Presynapse Formation Assay Using Presynapse Organizer Beads and &ldquo;Neuron Ball&rdquo; Culture
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SNAP-25, a Known Presynaptic Protein with Emerging Postsynaptic Functions.

Flavia Antonucci1, Irene Corradini2, Giuliana Fossati3

  • 1Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano Milan, Italy.

Frontiers in Synaptic Neuroscience
|April 6, 2016
PubMed
Summary

Synaptic protein SNAP-25 regulates neurotransmitter release and postsynaptic functions. Alterations in SNAP-25 may contribute to psychiatric disorders like ADHD by affecting both presynaptic and postsynaptic neuronal activities.

Keywords:
SNAP-25brain diseasespostsynaptic rolepresynaptic rolesynaptopathies

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An Optical Assay for Synaptic Vesicle Recycling in Cultured Neurons Overexpressing Presynaptic Proteins
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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Synaptic function relies on protein complexes; modifications impact neuronal networks.
  • SNAP-25 is crucial for SNARE complex function in synaptic vesicle exocytosis.
  • SNAP-25 interacts with calcium channels, modulating intracellular calcium dynamics.

Purpose of the Study:

  • To review the multifaceted roles of SNAP-25 in synaptic function.
  • To explore the potential contribution of SNAP-25 alterations to psychiatric disorders.
  • To investigate SNAP-25's influence on both presynaptic and postsynaptic mechanisms.

Main Methods:

  • Literature review of recent research on SNAP-25.
  • Analysis of studies linking SNAP-25 to synaptic vesicle exocytosis and calcium channel modulation.
  • Examination of evidence for SNAP-25's role in postsynaptic processes.

Main Results:

  • SNAP-25 controls presynaptic exo/endocytic processes.
  • SNAP-25 regulates postsynaptic receptor trafficking, spine morphogenesis, and plasticity.
  • SNAP-25 gene is associated with ADHD, schizophrenia, and bipolar disorder.

Conclusions:

  • SNAP-25 defects may underlie psychiatric diseases by affecting presynaptic and postsynaptic functions.
  • Understanding SNAP-25's dual role offers new insights into synaptopathies.
  • Further research is needed to define the precise mechanisms linking SNAP-25 alterations to psychiatric conditions.