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Updated: Mar 23, 2026
Half-segmental Diaphyseal Bone Defect Model in Rats for Evaluating Bone Substitute Performance in Load-bearing Regions
Published on: December 30, 2025
BIOMATERIAL IMPLANTS IN BONE FRACTURES PRODUCED IN RATS FIBULAS
Henrique Yassuhiro Shirane1, Diogo Yochizumi Oda1, Thiago Cerizza Pinheiro2
1Third-year medical student at the Jundiaí School of Medicine, Jundiaí, SP, Brazil.
Unlabelled:
To evaluate the importance of collagen and hydroxyapatite in the regeneration of fractures experimentally induced in the fibulas of rats.
Method:
15 rats were used. These were subjected to surgery to remove a fragment from the fibula. This site then received a graft consisting of a silicone tubes filled with hydroxyapatite and collagen.
Results:
Little bone neoformation occurred inside the tubes filled with the biomaterials. There was more neoformation in the tubes with collagen.
Conclusion:
The biomaterials used demonstrated biocompatibility and osteoconductive capacity that was capable of stimulating osteogenesis, even in bones with secondary mechanical and morphological functions such as the fibula of rats.
