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Trace elements levels in centenarian 'dodgers'.

Rafael Alis1, Alejandro Santos-Lozano2, Fabian Sanchis-Gomar3

  • 1School of Medicine and Research Institute "Dr. Viña Giner", Molecular and Mitochondrial Medicine, Catholic University of Valencia San Vicente Mártir, Valencia, Spain; Servicio de Nefrología, Hospital Universitario y Politécnico La Fe, Valencia, Spain.

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
|April 7, 2016
PubMed
Summary
This summary is machine-generated.

Healthy centenarians, or 'dodgers', exhibited distinct trace element profiles, with lower copper and higher iron and selenium levels compared to younger controls. This suggests a potential role for specific trace elements in promoting healthy aging and disease resistance.

Keywords:
AgingCopperLifespanSelenium

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Area of Science:

  • Gerontology and Nutritional Science
  • Biochemistry and Metabolism

Background:

  • Trace element bioavailability influences metabolic and physiological pathways affected by aging.
  • Understanding trace element associations with longevity can offer insights into healthy aging mechanisms.

Purpose of the Study:

  • To investigate the association between circulating trace element levels and increased lifespan in healthy centenarians ('dodgers').
  • To compare trace element profiles of centenarians with younger elderly controls.

Main Methods:

  • Analysis of seven circulating trace elements (Cr, Cu, Fe, Mn, Mo, Se, Zn) in centenarians and sex-matched elderly controls.
  • Statistical analysis including logistic regression and receiver operating characteristic (ROC) analysis to identify predictors of successful and healthy aging.

Main Results:

  • Centenarians displayed significantly lower copper (Cu) levels but higher iron (Fe) and selenium (Se) levels compared to controls.
  • Logistic regression identified a combination of Cu and Se as significant predictors of successful aging.
  • ROC analysis confirmed Cu and Se as independent variables associated with healthy aging.

Conclusions:

  • An 'improved' trace element profile, characterized by reduced Cu and elevated Se, may contribute to disease resistance in centenarians.
  • These findings suggest that specific trace element profiles are linked to the healthy aging phenotype.
  • Further research in larger, diverse cohorts and mechanistic studies are warranted to confirm these associations.