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Updated: Mar 23, 2026

Pooled shRNA Library Screening to Identify Factors that Modulate a Drug Resistance Phenotype
Published on: June 17, 2022
Advance in the study on p38 MAPK mediated drug resistance in leukemia
1Department of Pediatrics of Affiliated Hospital of Sichuan Medical University, Luzhou, Sichuan Province, China. liuwenjunsc@163.com.
Abstract:
Leukemia is a group of malignant clone diseases of hematopoietic stem cells, while drug resistance (DR) has become the primary cause of chemotherapy failure. p38 mitogen-activated protein kinase (p38MAPK) signaling pathway induces cell activation, proliferation and apoptosis in response to extracellular stimuli. Recent studies have shown that p38 MAPK signaling pathway is closely associated with DR in leukemia. The present article reviews the relationship between p38 MAPK signaling pathway and DR in leukemia.
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