Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

610
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
610
The Oral Microbiota01:27

The Oral Microbiota

7
The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
7
Cancer Prevention02:59

Cancer Prevention

8.7K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
8.7K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

5.0K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
5.0K
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

4.1K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
4.1K
Tumor Progression02:07

Tumor Progression

7.8K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Speech-based system for detecting alcohol intoxication using optimized deep learning.

Psychopharmacology·2026
Same author

Impact of maturity stages and modification processes on resistant starch and starch properties of green banana flour and its glycaemic response.

International journal of biological macromolecules·2025
Same author

Large Region of Homozygous (ROH) Identified in Indian Patients with Autosomal Recessive Limb-Girdle Muscular Dystrophy with p.Thr182Pro Variant in <i>SGCB</i> Gene.

Human mutation·2025
Same author

Communication of Autonomous Vehicles in Road Accidents for Emergency Help in Healthcare Industries.

Journal of healthcare engineering·2022
Same author

NF-KB A KEY TRANSCRIPTION FACTOR IN DISEASE PROGRESSION OF PATIENTS WITH COVID-19.

Annals of Ibadan postgraduate medicine·2022
Same author

Boundaries tuned support vector machine (BT-SVM) classifier for cancer prediction from gene selection.

Computer methods in biomechanics and biomedical engineering·2021
Same journal

Original Article | Epstein-Barr Virus Seroprevalence and Associated Risk Factors in Head and Neck Squamous Cell Carcinoma: A Cross-Sectional Study from Aden, Yemen.

The Gulf journal of oncology·2026
Same journal

Editorial | Artificial Intelligence-Augmented Breast Ultrasound: Advancing Diagnostic Precision and Equity in Cancer Care in Kuwait.

The Gulf journal of oncology·2026
Same journal

Original Article | Immunohistochemical Expression of BCL2 (B cell lymphoma 2) in Invasive Breast Carcinoma and its Correlation with Clinicopathological Parameters.

The Gulf journal of oncology·2026
Same journal

Review Article | Diagnosis and Early Detection of Lung Cancer: Present and Future Approaches.

The Gulf journal of oncology·2026
Same journal

Case Report | Development of spontaneous subcutaneous emphysema in a case of squamous cell carcinoma of right lung during radiotherapy treatment a rare instance.

The Gulf journal of oncology·2026
Same journal

Lower Gastrointestinal Bleeding Revealing an Early-Stage Primary Anorectal Melanoma: A Case Report.

The Gulf journal of oncology·2026
See all related articles

Related Experiment Video

Updated: Mar 23, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
07:15

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

12.5K

Potential Co-Relation Between Chronic Periodontitis And Cancer - An Emerging Concept.

T G Shrihari1, V Vasudevan1, V Manjunath1

  • 1Department of Oral Medicine and Radiology, Krishnadevaraya College of Dental Sciences, Bangalore, Karnataka, India.

The Gulf Journal of Oncology
|April 7, 2016
PubMed
Summary
This summary is machine-generated.

Chronic periodontitis, driven by oral bacteria, promotes cancer development through sustained inflammation and immune suppression. Key mediators released during this process facilitate tumor growth and metastasis.

More Related Videos

Murine Model of Advanced Periodontitis Induced by Nylon Ligature in the Second Upper Molar
07:14

Murine Model of Advanced Periodontitis Induced by Nylon Ligature in the Second Upper Molar

Published on: May 30, 2025

1.1K
Isolation, Processing and Analysis of Murine Gingival Cells
09:47

Isolation, Processing and Analysis of Murine Gingival Cells

Published on: July 2, 2013

20.1K

Related Experiment Videos

Last Updated: Mar 23, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
07:15

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

12.5K
Murine Model of Advanced Periodontitis Induced by Nylon Ligature in the Second Upper Molar
07:14

Murine Model of Advanced Periodontitis Induced by Nylon Ligature in the Second Upper Molar

Published on: May 30, 2025

1.1K
Isolation, Processing and Analysis of Murine Gingival Cells
09:47

Isolation, Processing and Analysis of Murine Gingival Cells

Published on: July 2, 2013

20.1K

Area of Science:

  • Oral microbiology and immunology
  • Cancer biology and immunology

Background:

  • Periodontal disease involves bacterial infection, leading to chronic inflammation, bacteremia, and immune responses.
  • Long-term exposure to oral bacteria and toxins triggers immune evasion, releasing growth factors, free radicals, cytokines, and matrix metalloproteinases.

Purpose of the Study:

  • To analyze the role of chronic inflammatory mediators in chronic periodontitis.
  • To investigate the progression of periodontitis-associated inflammation to cancer.

Main Methods:

  • Review of evidence on inflammatory mediators in periodontitis.
  • Analysis of immune evasion mechanisms and their downstream effects.
  • Examination of immature myeloid cell involvement in inflammation and tumor progression.

Main Results:

  • Chronic inflammation releases factors like FGF, EGF, TGF-Beta, ROS, NOS, TNF-alpha, IL-1 Beta, IL-6, and MMP-9.
  • Immature myeloid cells contribute to immunosuppression and tumor progression.
  • Mediators activate transcription factors (NF-KB, STAT3) promoting cancer hallmarks.

Conclusions:

  • Chronic periodontitis mediators play a significant role in cancer progression.
  • Inflammatory pathways in periodontitis can drive genetic instability, proliferation, and metastasis.
  • Understanding these links is crucial for cancer prevention and treatment strategies.