Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

7.9K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
7.9K
Co-activators and Co-repressors02:04

Co-activators and Co-repressors

7.7K
Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
7.7K
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

9.5K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
9.5K
General Transcription Factors01:30

General Transcription Factors

5.7K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
5.7K
Master Transcription Regulators02:23

Master Transcription Regulators

7.2K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.2K
Regulation of Nuclear Protein Sorting01:45

Regulation of Nuclear Protein Sorting

2.5K
Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

BETA ENDORPHINS - HOLISTIC THERAPEUTIC APPROACH TO CANCER.

Annals of Ibadan postgraduate medicine·2020
Same author

Dual role of inflammatory mediators in cancer.

Ecancermedicalscience·2017
Same author

Potential Co-Relation Between Chronic Periodontitis And Cancer - An Emerging Concept.

The Gulf journal of oncology·2016
Same author

Potential correlation between periodontitis and coronary heart disease--an overview.

General dentistry·2012

Related Experiment Video

Updated: Oct 5, 2025

NF-κB-dependent Luciferase Activation and Quantification of Gene Expression in Salmonella Infected Tissue Culture Cells
10:57

NF-κB-dependent Luciferase Activation and Quantification of Gene Expression in Salmonella Infected Tissue Culture Cells

Published on: January 12, 2020

10.8K

NF-KB A KEY TRANSCRIPTION FACTOR IN DISEASE PROGRESSION OF PATIENTS WITH COVID-19.

T G Shrihari1

  • 1Department of Oral Medicine and Oral Oncology, Krishnadevaraya College of Dental Sciences, Bengaluru, India.

Annals of Ibadan Postgraduate Medicine
|January 31, 2022
PubMed
Summary

COVID-19, caused by SARS-CoV-2, involves immune cell activation via pattern recognition receptors (PRRs) triggering NF-κB. Targeting this NF-κB pathway may offer therapeutic strategies for better COVID-19 prognosis.

Keywords:
Glycoprotein's.PAMP's (Pathogen associated molecular patterns)PRR (Pattern recognition receptors)TLR's (Toll like receptors)

More Related Videos

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α
11:27

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α

Published on: November 2, 2018

9.3K
A Chromatin Immunoprecipitation Assay to Identify Novel NFAT2 Target Genes in Chronic Lymphocytic Leukemia
09:52

A Chromatin Immunoprecipitation Assay to Identify Novel NFAT2 Target Genes in Chronic Lymphocytic Leukemia

Published on: December 4, 2018

7.7K

Related Experiment Videos

Last Updated: Oct 5, 2025

NF-κB-dependent Luciferase Activation and Quantification of Gene Expression in Salmonella Infected Tissue Culture Cells
10:57

NF-κB-dependent Luciferase Activation and Quantification of Gene Expression in Salmonella Infected Tissue Culture Cells

Published on: January 12, 2020

10.8K
A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α
11:27

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α

Published on: November 2, 2018

9.3K
A Chromatin Immunoprecipitation Assay to Identify Novel NFAT2 Target Genes in Chronic Lymphocytic Leukemia
09:52

A Chromatin Immunoprecipitation Assay to Identify Novel NFAT2 Target Genes in Chronic Lymphocytic Leukemia

Published on: December 4, 2018

7.7K

Area of Science:

  • Immunology
  • Virology
  • Molecular Biology

Background:

  • COVID-19 is a global pandemic caused by the SARS-CoV-2 virus.
  • The virus possesses surface glycoproteins that act as pathogen-associated molecular patterns (PAMPs).
  • These PAMPs are recognized by pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs) 7 and 8 on immune cells.

Purpose of the Study:

  • To elucidate the role of NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) in COVID-19 pathogenesis.
  • To explore the potential of targeting NF-κB as a therapeutic strategy for COVID-19.
  • To identify NF-κB as a prognostic marker for disease progression.

Main Methods:

  • The study reviews the molecular mechanisms of SARS-CoV-2 recognition by immune cells.
  • It focuses on the activation pathway involving PRRs, TLRs, and subsequent NF-κB signaling.
  • The role of dysregulated NF-κB in inflammatory mediator production is examined.

Main Results:

  • Activation of NF-κB is a key event following SARS-CoV-2 recognition by immune cells.
  • Dysregulated NF-κB activity leads to the release of inflammatory mediators, contributing to COVID-19 progression.
  • Suppression of NF-κB activity shows potential in mitigating disease progression.

Conclusions:

  • NF-κB plays a critical role in the inflammatory response and disease progression in COVID-19 patients.
  • Targeting NF-κB presents a promising therapeutic avenue for managing COVID-19.
  • NF-κB activity can serve as a valuable prognostic marker for COVID-19.