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Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids01:21

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

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Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
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Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Analgesia and Pain Management01:25

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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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Cancer Therapies02:49

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Targeted Cancer Therapies02:57

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
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Related Experiment Video

Updated: Dec 14, 2025

Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting
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BETA ENDORPHINS - HOLISTIC THERAPEUTIC APPROACH TO CANCER.

T G Shrihari1

  • 1Department of Oral Medicine and Oral Oncology, Krishna Devaraya College of Dental Sciences and Hospital, Bangalore, Karnataka, India.

Annals of Ibadan Postgraduate Medicine
|July 17, 2020
PubMed
Summary

Beta-endorphins, natural pain relievers, show significant potential as a holistic cancer treatment. This review explores their anticancer activities, offering a promising, inexpensive, and side-effect-free therapeutic avenue.

Keywords:
CortisolHPA-axis.IL-1 βIL-6MeditationNF-KbSTAT-3StressTNF-α

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Area of Science:

  • Neuroendocrinology
  • Oncology
  • Immunology

Background:

  • Endorphins are endogenous neuropeptides with morphine-like effects, crucial in stress and pain response.
  • Beta-endorphins, enkephalins, and dynorphins interact with nervous and immune system receptors.
  • Despite advancements, cancer treatment morbidity remains high, necessitating novel therapeutic strategies.

Purpose of the Study:

  • To review the anticancer activities of beta-endorphins.
  • To explore the therapeutic potential of beta-endorphins in cancer treatment.

Main Methods:

  • Comprehensive literature search on PubMed and Google Scholar for studies on endorphins and cancer.
  • Inclusion of studies, reviews, and clinical trials.
  • Synthesis of key findings from relevant research.

Main Results:

  • Beta-endorphin, synthesized in the pituitary, is a potent endogenous opioid.
  • It exhibits diverse mechanisms including analgesia, anti-inflammatory, immune stimulation, and stress reduction.
  • Beta-endorphin acts as a precursor to proopiomelanocortin (POMC).

Conclusions:

  • Beta-endorphin presents a natural, holistic approach for cancer prevention and treatment.
  • It offers preventive, therapeutic, promotive, and palliative benefits.
  • Beta-endorphin provides an inexpensive and side-effect-free cancer therapy option.