Hodgkin lymphoma: A clinicopathological and immunophenotypic study

Area of Science:

• Oncology
• Hematology
• Pathology

Background:

• Hodgkin lymphoma (HL) diagnosis relies on histology and immunophenotype.
• Understanding HL subtypes and their characteristics is crucial for patient management.

Purpose of the Study:

• To analyze clinical features, histomorphology, and immunoprofile of over 200 HL patients in India.
• To determine the relative frequency of HL histological subtypes based on WHO classification.
• To correlate subtypes with age and sex distribution in the Indian population.

Main Methods:

• Retrospective review of HL cases diagnosed between 2006 and 2009.
• Histopathology review of lymph node and bone marrow biopsies.
• Immunohistochemistry analysis including CD15, CD30, CD20, and ALK.

Main Results:

• Bimodal age distribution observed, with HL appearing a decade earlier than in Western populations.
• Mixed cellularity (67%) was the most frequent subtype, followed by nodular sclerosing (23.5%).
• Archetypical classical HL (CHL) immunophenotype (CD15+, CD30+, CD20-) was most common (60.6%); CD15 negativity and CD20 positivity were noted in 35.8% and 17.5% of CHL cases, respectively.

Conclusions:

• This study provides a comprehensive overview of clinical, histopathological, and immunophenotypic profiles of HL in India.
• Findings highlight regional variations in HL presentation and subtype frequency.
• The data contributes to a larger understanding of HL epidemiology and characteristics.