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Mass Spectrometry and Luminogenic-based Approaches to Characterize Phase I Metabolic Competency of In Vitro Cell Cultures
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[EVALUATION OF THE PHARMACOKINETIC INTERACTION OF AFOBAZOLE WITH CYP2C9 ENZYME DRUG SUBSTRATE OF CYTOCHROME P450]

O G Gribakina, G B Kolyvanov, A A Litvin

    Eksperimental'Naia I Klinicheskaia Farmakologiia
    |April 8, 2016
    PubMed
    Summary

    Afobazole did not alter cytochrome P450 isoenzyme CYP2C9 activity at a 5 mg/kg dose in rats. However, a higher afobazole dose (25 mg/kg) indicated CYP2C9 isoenzyme induction, affecting drug metabolism.

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